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The acid-base-balance is a crucial basic function of the human body. Cell energy is always accompanied by the formation of acids

The body is extremely well placed to keep the acid-base ratio in balance, i.e. excrete acids through the kidneys, lungs, intestines and skin. However, it must be taken into account that every biological system can exhaust itself.This appears optically as a macrocosm, but the crucial vital functions take place in the microcosm, in the cell and in the basic tissue.

We then feel ‘drained’, lacking in drive, uncomfortable, have circulatory disorders, joint problems, chronic pain, allergies, kidney stones, osteoporosis etc. Typical demineralization through acidification occurs acidosis.

The reduction in buffer capacity that precedes acute acidosis is called latent acidosis. This condition, which can also be determined by means of Jörgensen’s blood serum analysis (pH buffer capacity measurement), is very common in patients.

(Procaine-)Base-short-infusion

In the meantime, the problem of local acidification in the microenvironment of tumours is receiving increasing attention and could open up new perspectives  in supportive biological cancer therapy (increases in effectiveness of immunotherapy by improving blood circulation and alkalization in the microenvironment of tumours).

The sole successful use of base infusions was by Dr. Michael Worlitschek described. However, due to the lack of ‘widening’ of small peripheral vessels, the effects lag behind those of infusion therapy with procaine bases.

Procaine is characterized as a local anesthetic with low toxicity, good controllability, serum breakdown and high regulatory potency. From a chemical point of view, procaine is a basic ester that is only soluble as an acid salt (e.g. as hydrochloride).

For their possible solubility in water, the injection solutions have a pH value of 4-6. The body tissue with a pH value of 7.45 acts as a buffer.

An acidic environment in the tissue, for example in the case of inflammation, reduces the effect of the local anesthetic procaine. A physiological base (sodium hydrogen carbonate) is therefore added to the infusion solution to reduce early dissociation with subsequent degradation in the serum. By adding sodium bicarbonate solution 8.4%, the pH value of the infusion solution and thus the proportion of non-dissociated and with it membrane-compatible procaine molecules is increased.

This enables higher peripheral flooding rates of procaine to be achieved.

The sole successful use of base infusions was by Dr. Michael Worlitschek described. However, due to the lack of ‘widening’ of small peripheral vessels, the effects lag behind those of infusion therapy with procaine bases.

Eu-Ru Med